The Pilgrims, managed by Manchester United legend Wayne Rooney, sit 21st in the Sky Bet Championship table, two points above the relegation zone.
Argyle though boast an impressive home record, with four wins and three draws from their eight league matches at Home Park.
We picked out six players to keep an eye on this weekend.
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Adam Forshaw
The experienced 33-year-old midfielder joined the Pilgrims in January following a stint at Norwich City.
His career began at Everton, with spells at Brentford and Wigan Athletic prior to joining Middlesbrough in January 2015.
Forshaw made 103 appearances in just under three years, and signed for Leeds United in a £4.5 million switch in January 2018.
He made 91 appearances for the Elland Road outfit, including 46 in the Premier League, and had a brief spell with the Canaries before joining Argyle.
Darko Gyabi
England Under-21 midfielder Gyabi is on loan from Elland Road, following another loan stint last season.
Originally on the books at Manchester City, he joined Leeds for £5m in July 2022, and moved to the Pilgrims on loan in January.
After nine starts and one substitute appearance, a groin injury cut short his temporary move, but he returned to Argyle in the summer.
Kyle Edwards is set for a full return to training as Des Buckingham addresses the winger’s long-term future #oufc https://t.co/6eueBf1ajJ
— Oxford Mail OUFC (@OxfordMailOUFC) December 3, 2024
Adam Randell
The Plymouth-born 24-year-old midfielder made his debut in November 2018, and in total, has played 147 times for the Pilgrims, scoring 10 goals.
He played 42 Vanarama National League games for Torquay United during a loan spell in the 2020/21 campaign.
Bali Mumba
Versatile left-sided player Mumba initially joined Argyle on loan from Norwich for the 2022/23 season, when he helped the Pilgrims lift the League One title.
He scored six goals in 41 league matches, prompting Argyle to sign him on a permanent basis following promotion.
The Pilgrims spent a reported £1m to secure Mumba, and he has since played a further 66 games for the club.
Morgan Whittaker
The 23-year-old attacker is no doubt Argyle’s biggest goal threat. He had spells at Derby County and Swansea City earlier in his career, and joined the Pilgrims on loan from the Swans for the 2022/23 campaign.
After bagging nine goals in 25 league games, he was recalled, but then signed for Argyle last summer in a £1m move.
Whittaker has since netted 22 goals in 61 league matches, but has been struggling with a toe injury in recent weeks, and there are doubts as to his availability this weekend.
The 33-year-old striker has scored three goals in seven appearances since joining the Pilgrims on a short-term deal in October.
The goals flowed for Luton Town and Brentford at the start of his career, prior to a £9m move to Burnley in August 2015.
He scored 32 goals in 73 league games, and then joined Watford for a reported £18.5m in August 2017.
Gray has 23 goals in 115 Premier League appearances in total, and joined Argyle after spells in Greece and Saudi Arabia.