Hill Residential is planning to build the properties on land north of Goose Green.
The development will form part of the Oxford North quarter, with the site bordering the Canalside residential development.
Once complete, the £700m development will feature a total of 480 new homes and one million sq ft of laboratory and workspaces.
There will also be a hotel, nursery, cafes, bars, and three public parks.
The major scheme is recommended for permission and will be decided by Oxford City Council’s planning committee on Tuesday, September 17.
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It has received 18 objections and one supporting comment.
Sami Cornell, of Goose Green Close, said: “My home is going to be massively effected by this as I live on Goose Green Close, I will have no privacy as the new development will overlook my property I have a small garden and this is going to be far to close to my property.
“The area is still full of so much wildlife and the Oxford North development has restricted their habitat massively already there is going to be no green space left.”
Nick Malden, of Godstow Road, said: “The local school is full and our GP surgery is at breaking point so more houses will exacerbate these issues. We are also concerned about the flood risk in a low-lying area. More houses will adversely affect the habitat for wildlife and reduce biodiversity.”
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Steve Morgan, also of Godstow Road, added: “Wolvercote has become significantly over developed without any thought or consideration to the local infrastructure and natural environment. The Oxford North development will bring an additional 4,500 new jobs and the impact on the roads will be horrendous.
“Adding more properties to an already overdeveloped area would likely lead to increased traffic congestion. This not only impacts the daily lives of residents but also poses safety risks and contributes to air pollution.”
Supporter Keith Zimmerman, of Carey Close, Oxford, said: “This country, county and neighbourhood need more homes. The lack of new homes being built is one of the greatest drivers of inequality in our community.
“This development is on marginal land relative to the many important areas that should be and are protected, e.g. Wytham and Meadow. I am a strong supporter of such developments and would seriously consider moving to one of these properties.”
For more details about the planning application online, search 24/00318/FUL on Oxford City Council’s planning portal.