Wondering about the best wager among all 16 NFL matchups in Week 2? Our pick, in terms of the point spreads, is Vikings +6. But see below, because we have lots more tips, and that could lead to parlay possibilities.

Best Week 2 Spread Bets

Jump to Matchup:

Pick: Giants +1.5 vs. Commanders

• Matchup: New York Giants at Washington Commanders
• Projected Winner & Margin: Giants by 11.0 points (Bet on this game at BetMGM)
• Spread: Commanders -1.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Rams +1.5 vs. Cardinals

• Matchup: Los Angeles Rams at Arizona Cardinals
• Projected Winner & Margin: Rams by 11.0 points (Bet on this game at BetMGM)
• Spread: Cardinals -1.5
• Time: 4:05 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Dolphins -2.5 vs. Bills

• Matchup: Buffalo Bills at Miami Dolphins
• Projected Winner & Margin: Dolphins by 3.0 points (Bet on this game at BetMGM)
• Spread: Dolphins -2.5
• Time: 8:15 PM ET
• Date: Sept. 12
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Browns +3 vs. Jaguars

• Matchup: Cleveland Browns at Jacksonville Jaguars
• Projected Winner & Margin: Browns by 4.0 points (Bet on this game at BetMGM)
• Spread: Jaguars -3
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Patriots +3.5 vs. Seahawks

• Matchup: Seattle Seahawks at New England Patriots
• Projected Winner & Margin: Patriots by 13.0 points (Bet on this game at BetMGM)
• Spread: Seahawks -3.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 2 Total Bets

Jump to Matchup:

Under 45.5 – 49ers vs. Vikings

• Matchup: San Francisco 49ers at Minnesota Vikings
• Projected Total: 42.5 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Over 45.5 – Saints vs. Cowboys

Over 45.5 – Bears vs. Texans

Under 38 – Seahawks vs. Patriots

Over 36.5 – Steelers vs. Broncos

• Matchup: Pittsburgh Steelers at Denver Broncos
• Projected Total: 37.0 points (Bet on this game at BetMGM)
• Time: 4:25 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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