What’s the best bet to make, looking at each of the 14 matchups on the NFL’s Week 5 slate? Our favorite point-spread choice is Colts +3, but we have lots more suggestions for you, which could lead to parlay possibilities, below.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 5 Spread Bets

Jump to Matchup:

BUF-HOU | MIA-NE | TB-ATL | NYJ-MIN | BAL-CIN

Pick: Texans +1 vs. Bills

• Matchup: Buffalo Bills at Houston Texans
• Projected Winner & Margin: Texans by 2.1 points (Bet on this game at BetMGM)
• Spread: Bills -1
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Patriots -1 vs. Dolphins

• Matchup: Miami Dolphins at New England Patriots
• Projected Winner & Margin: Patriots by 4.0 points (Bet on this game at BetMGM)
• Spread: Patriots -1
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Buccaneers +1.5 vs. Falcons

• Matchup: Tampa Bay Buccaneers at Atlanta Falcons
• Projected Winner & Margin: Falcons by 0.7 points (Bet on this game at BetMGM)
• Spread: Falcons -1.5
• Time: 8:15 p.m. ET
• Date: Oct. 3
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Vikings -2.5 vs. Jets

• Matchup: New York Jets vs. Minnesota Vikings
• Projected Winner & Margin: Vikings by 5.2 points (Bet on this game at BetMGM)
• Spread: Vikings -2.5
• Time: 9:30 a.m. ET
• Date: Oct. 6
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bengals +2.5 vs. Ravens

• Matchup: Baltimore Ravens at Cincinnati Bengals
• Projected Winner & Margin: Ravens by 1.2 points (Bet on this game at BetMGM)
• Spread: Ravens -2.5
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 5 Total Bets

Jump to Matchup:

Over 42.5 – Saints vs. Chiefs

Under 43 – Cowboys vs. Steelers

Under 43.5 – Buccaneers vs. Falcons

Under 50.5 – Ravens vs. Bengals

• Matchup: Baltimore Ravens at Cincinnati Bengals
• Projected Total: 50.0 points (Bet on this game at BetMGM)
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Under 48 – Packers vs. Rams

• Matchup: Green Bay Packers at Los Angeles Rams
• Projected Total: 47.9 points (Bet on this game at BetMGM)
• Time: 4:25 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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