The concert, in aid of Helen & Douglas House, will take place on Thursday, November 28.
The Oxford-based charity helps children with life-shortening conditions and their families.
The concert will feature performances from Frideswide Voices girls’ choir and the Lay Clerks of Christ Church Cathedral.
The University of Oxford’s a cappella group, Out of the Blue, will also perform and debut their 2024 Christmas single.
Ben Reddy from Out of the Blue said: “It is such a privilege to be able to support this amazing charity through our“We are so excited to perform in such a beautiful location and to help spread some festive cheer.”
There will also be festive readings from families supported by the hospice, as well as from Mr Blanc and actor Anthony Calf.
Mr Blanc said: “Food, like music, has the power to bring people together and create cherished memories.
“I’m honoured to be part of the Helen & Douglas House Christmas Concert, sharing the spirit of the season and supporting the vital work they do in our community.”
The concert will take place between 8pm and 9.30pm, with doors opening at 7.15pm.
Tickets are available from £15 to £50, with proceeds going to Helen & Douglas House.